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Old 01-31-2012, 08:57 PM
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Default Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused?

Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused?

It takes longer for people to get high from this oral form of marijuana, so there is little potential for abuse

By Rachael Rettner and MyHealthNewsDaily | January 31, 2012

The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

The British pharmaceutical company GW Pharmaceuticals is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharmaceuticals told MyHealthNewsDaily.

The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.

Because the drug contains THC, the ingredient primarily responsible for marijuana's "high," it's possible people would use the drug for recreational rather than medical purposes.

"There is no doubt in my mind that there will be people that abuse it," said Dr. Jeffrey Bernstein, director of the Florida Poison Information Center at the University of Miami Miller School of Medicine.

However, because the drug is delivered through ingestion, rather than smoking, it would take much longer to have an effect ó at least an hour, compared with the minutes it takes to get high after smoking marijuana, said Margaret Haney, a professor of clinical neurobiology at Columbia University. This means drug users seeking a high would be less likely to abuse it. "Smoking is a really effective way to get a chemical into the brain," Haney said. The mouth spray "is a far safer administration,"she said.

And Marinol and Cesamet, which are also administered orally, have a low rate of abuse. "We donít see a lot of problems from [those]," Bernstein said.

Not the same high
GW Pharmaceuticals intends to market Sativex in the United States for treatment of cancer pain. The drug is already approved in United Kingdom, Spain, Canada and New Zealand to treat muscle spasms due to multiple sclerosis, according to the company website.

Patients can adjust the dose of Sativex to prevent it from entering the blood too rapidly, allowing them to experience symptom relief without the marijuana high, according to GW Pharmaceuticals.

In addition, while marijuana is a hodgepodge of about 64 different substances, Sativex is composed mainly of two ingredients: THC and another cannabinoid called CBD. The latter component is thought to ameliorate some of the side effects of THC, including the high that marijuana users feel, said Dr. Armando Villarreal, an assistant professor of neurosurgery and pain management at the University of Rochester Medical Center in New York.

And for habitual marijuana users, the cultural and ritualistic practices that go along with smoking pot, such as passing a joint, may be an important part of the experience, Bernstein said. These rituals cannot be replicated with the spray. "A lot of people that smoke marijuana would rather smoke it," he said.

Unlikely overdose
Unlike drugs such as painkillers, which come with a risk of death if people take too much, patients who "overdose" on the marijuana spray would be at little risk for acute health problems, Haney said.

"What could happen is the person could get very uncomfortably intoxicated," Haney said. But in terms of other serious health effects, "there's none that I know of," Haney said.

Source: Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused?: Scientific American
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Old 01-31-2012, 09:36 PM
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make yer own for a 10x of the cost


and the effects are noticed in 30sec to 2 mins and last about an hour not sure what the are talking about ingesting it.
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Old 01-31-2012, 09:47 PM
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Coop, you are quite right, in that we CAN make this ourselves - providing the cannabinoid ratios are high enough, and that there is enough CBD. I see folks using the Z-series plants for this, which have a 1:1 THC/CBD ratio.
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Old 01-31-2012, 09:48 PM
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yea that's my goal right now, is to find some cbd herb to extract. Mine are only thc right now.

But on paper it should be pretty simple to extract the two and compound them in the necessary ratios.
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Old 01-31-2012, 09:50 PM
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Very cool. I see you doing God's work making medicine like this. Much respect!!!
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Old 01-31-2012, 10:00 PM
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Quote:
Originally Posted by coop View Post
make yer own for a 10x of the cost


and the effects are noticed in 30sec to 2 mins and last about an hour not sure what the are talking about ingesting it.
Hey coop,

Ya Moose he is deffinetly doing Gods work. I have been lucky enough to test this type of sublingual spray and found it to work for some but not all. From my trials it seems that some people respond very well with the sublingual spray but for others there is no comparissan to smoking it.

I would fall into the later. But for someone like my uncle who is fighting bone marrow cancer and needs pain relief and appetite encouragement, I think they will be useful.

Also, the taste was surprisingly good, especially the SSH that I tried, the one without the glycerine.

Best Regards

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Old 01-31-2012, 10:05 PM
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yea there has been a lot of trail and error making tinctures that is for sure.

its great to have access to a lab to test my products and know where my mistakes lie in making it.

Moose, I'm sure your aware of greywolfs work over on ICmag. His HolyShitOil is something that I've been playing around with recently and will say the addition of cinnamon oil to both my tinctures and the spray seem to really increase the effectiveness.


The biggest issue I found is making a proper decarboxilated extract. Refining it is actually quite easy. But making sure its activated properly is where the issue lies sometimes.

I also notice the addition of glycerin to some of the mixes where pulling the thc out of the solution. If you shake them before you use it not much of an issue, but its not what I was looking for.
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Old 01-31-2012, 10:15 PM
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Greywolf has also been posting at TY. He is doing some ground breaking work, not just with tinctures.
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Old 01-31-2012, 10:19 PM
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for sure, its amazing to see the work that has been sprung from foaf's honeypot.

I really think we are going to see some truly amazing things in the next year or two, and even more amazing that its the individuals doing it.
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Old 02-01-2012, 12:12 AM
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coop youre a mad scientist!

im off to the lab myself! hahaha.
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