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Old 05-20-2017, 03:06 PM
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Talking Aripiprazole/THC interactions

Since aripiprazole may bind to anandamide, the activation of intracellular cannabinoid receptors by anandamide may increase the effects of CYP2D6, a key enzyme involved in aripiprazole functional selectivity to dopamine D2 receptors.

It is therefore quite hilarious to prescribe a potential endocannabinoid transporter and selective CYP2D6 substrate in order to stabilize the dopamine system!

Aripiprazole, a third-generation antipsychotic, is probably the most biocompatible substrate for chronic cannabis users. I describe the activation of endogenous cannabinoids (anandamide) by aripiprazole as a genuine and
highly psychoactive experience of lucidity!

Disclaimer: I do not recommend anyone to visit a psychiatrist in order to get aripiprazole... Aripiprazole may not be suitable for everyone. Furthermore, you should ask your psychiatrist before attempting to experiment with cannabis and aripirazole.

Peace

tkadm30

Last edited by tkadm30; 07-23-2017 at 09:12 AM.
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Old 05-21-2017, 01:52 PM
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https://www.reddit.com/r/DrugNerds/c..._you_tried_it/

Oilahuasca Activation - HerbPedia

more to find via google
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Old 05-21-2017, 08:05 PM
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No thanks... I prefer to stick with MMJ, as this kind of shit (oilahuasca) can be unsafe for peoples who use aripiprazole.

Heck, I don't recommend anyone to play with this type of drug.

Last edited by tkadm30; 05-21-2017 at 08:10 PM.
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Old 02-03-2018, 09:56 AM
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Abstract:

Delta(9)-THC may prevent long-term damage to dopamine neurons caused by aripiprazole.

Research highlights:

Delta(9)-THC may act as a dopamine transcription factor and may efficiently prevent antipsychotic-induced dopaminergic dysfunction.

Delta(9)-THC may prevent/reduce aripiprazole-induced dopamine blocking.

Delta(9)-THC is potential neuroprotective agent for aripiprazole withdrawal.
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Last edited by tkadm30; 02-03-2018 at 09:58 AM.
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Old 02-03-2018, 10:30 AM
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Thanks for the link Deran.
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Old 02-03-2018, 12:55 PM
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Is it possible that the neuroprotective properties of delta(9)-THC may reverse or prevent antipsychotic-induced dopaminergic alterations?

tk
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Old 02-03-2018, 02:46 PM
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I would be almost as wary of aripiprazole as I would be of oilahuasca. Ayahuasca (granted, NOT oilahuasca) has been used much longer than aripiprazole. MANY psychiatric drugs are worse than what they are supposed to treat. I won't say designed to treat as it is almost always more of a shotgun approach of finding chemicals with certain attributes and throwing them at the problem.
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Old 02-03-2018, 05:22 PM
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Quote:
Originally Posted by PlantManBee View Post
I would be almost as wary of aripiprazole as I would be of oilahuasca. Ayahuasca (granted, NOT oilahuasca) has been used much longer than aripiprazole. MANY psychiatric drugs are worse than what they are supposed to treat. I won't say designed to treat as it is almost always more of a shotgun approach of finding chemicals with certain attributes and throwing them at the problem.
The comparison is surely interesting. Except that aripiprazole is a partial dopamine agonist (antipsychotic) while ayahuasca (oilahuasca?) is a psychedelic (hallucinogen) drug.
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