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HHHG 11-15-2014 09:30 AM

THC+CBD Shrinks Highly Aggressive Brain Tumors
 
A tandem approach to shrinking brain tumors with two of marijuana’s key ingredients — tetrahydrocannabinol and cannabidiol — has proven successful, according to the result of a newly published study.

Senior author of the new study, Dr. Wai Liu, of the University of London, says the one-two punch of THC and CBD is really what makes cannabis yield such impressive effects.


“We think this is due to the different pathways that these cannabinoids hit,” Liu told Medical Daily in an email. “Specifically, THC works via receptors, whilst CBD may not need them; consequently, using them together results in a ‘priming’ effect in tumour cells, making them more sensitive to the ‘cell killing’ effects of irradiation.”


Liu’s study in mice models found THC and CBD, when used together, helped shrink the tumors to a far greater extent than radiation and just one of the compounds or radiation alone, which actually yielded a negligible effect on tumor growth. What’s more, the team needed a smaller dosage of each substance when they were used together in order to kill 50 percent of the cancer cells. They needed 14 millimolar (a unit of concentration) of CBD and 19 millimolar of THC. Using both, they needed only seven millimolars each.


This finding is especially important because it means patients won’t need as much THC, the main psychoactive ingredient in cannabis that may be unpleasant for people receiving treatment. When a psychoactive compound binds to the cannabinoid receptor inside a brain cell, it can trigger the traditional “high” effects of recreational use. But in small enough doses, the compound can retain its anti-cancer properties without any side effects. The trick is to find the balance, Liu says.


So what’s actually going on that allows cannabis to be so effective? Liu suspects the answer has to do with how the substances interact with the receptors and the radiation treatment.


“We think that the cannabinoids are hitting a number of cell signaling pathways, which primes them to the effects of irradiation,” he said. “Pre-treatment with the cannabinoids seems to interfere with the ability of the tumour cell to repair the DNA-damaging effects of irradiation.” Thus, the tumor cells get wiped out.


There are more than 85 cannabinoids in total, which bind to different receptors in cells and receive outside chemical signals. The brain houses many of these receptors, and prior evidence has already shown cannabis to destroy certain cancer cells, giving the researchers a natural starting point to see how THC and CBD work together. Their targets — glioma cells — are notoriously hard to kill with standard methods. Fewer than five percent of people who survive glioblastoma, a form of glioma, live past three years.


Killing these cancer cells has never been more crucial, as medical science continues to peel back the layers of cannabis’s medicinal benefits. We may have a simple, effective, and safe treatment to help cancer patients, but without a social or legal framework in place to allow the method’s use, it becomes worthless. Though, people like Liu remain hopeful.



“The results are promising,” he wrote recently. “There may be other applications, but for now it could provide a way of breaking through glioma and saving more lives.”


Cannabis Shrinks Brain Tumors Associated With Highly Aggressive Form Of Cancer

Talpa 11-15-2014 09:54 AM

Hi HHHG

GW Pharma are currently carrying out trials with sativex/CBD THC.

GWPharma - GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM)

Personally great news but hard to understand why the UK government will grant a licence and allow a pharma company to grow cannabis when according to UK law cannabis has no medical use.

Let us grow our own medicine legally.

Al Capone 11-15-2014 02:00 PM

Quote:

Originally Posted by Talpa (Post 209030)
Hi HHHG

GW Pharma are currently carrying out trials with sativex/CBD THC.

GWPharma - GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM)

Personally great news but hard to understand why the UK government will grant a licence and allow a pharma company to grow cannabis when according to UK law cannabis has no medical use.

Let us grow our own medicine legally.

They don't want us to grow our own they want us to pay them you should see the list of patents GW has seems like the only thing they don't have one on is the flower itself. It's going to be a long time for full legalization but 10-20 years we may finally have it once the Reefer Madness generation dies off.

Talpa 11-15-2014 02:39 PM

I know they don't and I have seen. Locking out the competition. Its the US that has a patent on the flower.

Betterhaff 11-15-2014 05:08 PM

I think the only patent the US Govt has is US Patent # 6630507. It applies to any and all uses and applications of Cannabinoids as antioxidants and neuroprotectants.

fxginbcn 11-15-2014 05:13 PM

the US Govt owns the patent on CBD as well

Betterhaff 11-15-2014 05:26 PM

1 Attachment(s)
I think thatís all inclusive in the above patent although only pertaining to the stated uses and applications.

Talpa 11-15-2014 08:47 PM

Hey its close enough lol. Lets just say they have us screwed.

HHHG 11-16-2014 07:49 AM

1:1
 
The use of 1:1 for medicinal use is old news, but it's good to get new studies on it, especially pertaining to cancer.


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