Mr. Nice Forums  
Home History Strains Media Web Community Medical Marijuana Contact us Auctions

Go Back   MNS Forums > Medicinal plants > 9. Patients forum

Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 01-27-2013, 08:06 PM
Smokin Moose's Avatar
Senior Member
 
Join Date: Jul 2009
Location: Somewhere deep in the mind's eye.
Posts: 935
Default Cancer: Do cannabinoids cure cancer?

Cancer: Do cannabinoids cure cancer?

by Dr Manuel Guzmán

Cannabinoids, the active components of cannabis and their derivatives, exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds inhibit the growth of tumour cells in laboratory animals -mice and rats. However, at the moment there is not solid evidence to prove that cannabinoids –whether natural or synthetic- can effectively treat cancer in patients, although research is ongoing around the world.

Comprehensive FAQ sections -including scientific references- on cannabinoids and cancer can be found at the Cancer Research UK website and the National Cancer Institute of the US website. Here that information is summarized and discussed.

What is cancer?
Cancer is a broad term used for diseases in which abnormal cells divide without control and are usually able to invade other tissues, causing metastases and high rates of mortality and morbidity. Cancer is not just one disease but many diseases: more than 100 different cancers are well-typified from a histopatological point of view by the WHO and, most likely, there are hundreds if not thousands types of cancers according to molecular and genetic profiling.
Most cancers are named for the organ or type of cell in which they start. In addition, cancer types are usually grouped into the following broader categories:
- Carcinoma: cancer that begins in the skin or in tissues that line or cover internal organs.
- Sarcoma: cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
- Leukaemia: cancer that starts in blood-forming tissues such as the bone marrow and causes large numbers of abnormal blood cells to be produced and enter the blood.
- Lymphoma and myeloma: cancers that begin in the cells of the immune system.
- Central nervous system cancers: cancers that begin in the tissues of the brain and spinal cord.

Conclusion: Cancer is a very serious and heterogeneous disease, so fighting it therapeutically remains an extremely difficult challenge. Cannabinoids might therefore exert beneficial effects in some cancers but not in others.

Do cannabinoids inhibit cancer growth? (Laboratory research)
Virtually all the research into cannabinoids and cancer cells has been conducted so far using cancer cells grown in the lab or in animal models. Many scientific studies have reported that various cannabinoids (both natural and synthetic) exert a wide range of growth-inhibiting effects on cancer cells, including:
- Triggering cell death, through a mechanism called apoptosis.
- Stopping cells from dividing.
- Preventing new blood vessels from growing into tumours –a process termed angiogenesis.
- Reducing the chances of cancer cells to metastasize through the body, by stopping cells from moving or invading neighbouring tissue.
- Speeding up the cell’s internal ‘waste disposal machine’ –a process known as autophagy – which can lead to cell death.

Conclusion: Cannabinoids are efficacious drugs to treat at least some types of cancers in laboratory animals –mice and rats.

Do cannabinoids inhibit cancer growth? (Anecdotal evidence in humans)
As mentioned above, basically all the research investigating whether cannabinoids can treat cancer has been done in the lab. It is therefore important to be very cautious when extrapolating these results up to real live patients, who are a lot more complex than a Petri dish or a mouse. Anecdotal reports on cannabis use have been historically helpful to provide hints on the biological processes controlled by the endocannabinoid system and on the potential therapeutic benefits of cannabinoids. In the precise case of cancer there is a notable presence of videos and reports on the internet arguing that cannabis can cure cancer. These anecdotal claims may be completely or partially true in some cases, but overall remain –at least to date- weak and obscure. For example:
- We do not know whether the (supposed) effect of cannabis was due to a placebo effect.
- We do not know whether the tumour has (supposedly) stopped growing by natural/endogenous reasons -some tumours regress spontaneously/owing to the body’s anti-tumour defences.
- We do not know how many patients have taken cannabis and have not obtained any therapeutic benefit, that is, what is the (supposed) efficacy of the cannabis-based therapy.
- As most likely patients have gone through standard therapy prior to or concomitantly with cannabis use, we do not know whether the (supposed) effect of cannabis was in fact due -at least in part- to the standard therapy -perhaps enhanced by cannabis, but we have no proof.
- We do not know what are the parameters of tumour progression that have been monitored and for how long the patient has been monitored -many potentially beneficial effects of antineoplastic drugs (or of cannabis in this case) are just short-term actions, but what about long-term progression-free survival and overall survival?
- Cancer is a very heterogeneous disease, and so far none has put together a sufficient number of patients for a particular type of cancer to support that cannabinoids are efficacious drugs in that precise cancer.

Conclusion: Although it is possible –and of course desirable- that cannabis preparations have exerted some antineoplastic activity in some particular cancer patients, the current anecdotal evidence reported on this issue is pretty poor, and, unfortunately, remains far from supporting that cannabinoids are efficacious anticancer drugs for large patient populations.

Do cannabinoids inhibit cancer growth? (Clinical research)
Results have been published from only one Phase I clinical trial testing whether cannabinoids can treat cancer in patients. Nine people with advanced, recurrent glioblastoma multiforme –an aggressive brain tumour– that had previously failed standard therapy were given highly purified THC through a catheter directly into their brain. Under these conditions cannabinoid delivery was safe and could be achieved without significant unwanted effects. In addition, although no statistically-significant conclusions can be extracted from such a small cohort of patients and without a control group, the results obtained suggested that some patients responded -at least partially- to THC treatment in terms of decreased tumour growth rate, as evaluated by imaging and biomarker analyses. These findings were encouraging and substantially reinforced the interest on the potential use of cannabinoids in cancer therapies. However, they also highlighted the need for further research aimed at optimizing the use of cannabinoids in terms of patient selection, combination with other anticancer agents and use of other routes of administration.

Conclusion: There are still many unanswered questions around the potential for using cannabinoids as anticancer drugs, and it is necessary and desirable that exhaustive clinical studies are conducted to determine how cannabinoids can be used, other than for their palliative effects, to treat cancer patients.

About the author
Dr Manuel Guzman is professor at the Department of Biochemistry and Molecular Biology at Complutense University in Madrid, Spain. He coordinates the Cannabinoid Signaling Group.

Source: International Association for Cannabis as Medicine
__________________
Each and every one of us can play the part of an activist to some degree. Being here at MNS is an act of activism. Simple as that. It all adds up until critical mass occurs, then change comes.

Last edited by Smokin Moose; 01-27-2013 at 08:41 PM.
Reply With Quote
  #2  
Old 01-27-2013, 10:28 PM
Member
 
Join Date: Jan 2013
Location: earth
Posts: 92
Default

nice post Smoking Moose.
cR
Reply With Quote
  #3  
Old 03-24-2013, 04:54 PM
Junior Member
 
Join Date: Sep 2010
Location: California
Posts: 2
Default

Greetings fellow Patients, Cultivators and Caregivers; I'm a Stem Cell/Kidney transplant survivor and living proof that Hemp Oil (medicinal properties of cannabis isolated using Food Grade Alcohol) KILLS and eradicates CANCER CELLS. Testimony from my collective members (4th stage cancer patients) may give hope to those who do not believe. I will cut and paste some of their letters to me:
My last blood readings showed a stable PSA!!! My PSA was rising quickly for three months before starting oil. The $7500 per month medicine did nothing.

I have a new hope now that I can control or beat this disease, thanks to you and my Sister insisting I try this treatment.

Please save at least two tubes for me. I plan to stay on the oil for next three months minimum.

Can you do this for me?

Gratefully yours,
Reply With Quote
  #4  
Old 03-24-2013, 05:37 PM
Senior Member
 
Join Date: Jan 2010
Posts: 346
Default

Spain Study Confirms Hemp Oil Cures Cancer without Side EffectsEndAllDisease.com
Reply With Quote
  #5  
Old 05-04-2013, 05:24 AM
Senior Member
 
Join Date: Jul 2012
Posts: 319
Default

At YouTube there is a video, Marijuana Cannabis Use In Pregnancy Dr. Dreher. In Jamaica she studied pregnant women who used cannabis to see if the cannabis mothers smoked would hurt their children.

Her results were very positive. Very worth while video.

Happyd's link has a link to Run From The Cure; The Rick Simpson Story that is also a very good info source if you haven't watched it.

If you can, get the DVD Grass narrated by actor Woody Harrilson. You don't wanna miss it. More along the line of cannabis history. You will get bang out of it. It's at Netflix & may be online, not sure. It has film from the 50's case studies included.

mM

Last edited by medMUser; 05-04-2013 at 05:26 AM.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On



All times are GMT. The time now is 06:42 AM.


Powered by vBulletin® Version 3.8.11
Copyright ©2000 - 2020, vBulletin Solutions Inc.
SEO by vBSEO 3.6.0 PL2
All rights reserved, MR NICE SEEDBANK, NL