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Old 10-14-2011, 07:30 AM
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donb great post

i'm just get up and running after officer dibble decided to rob all my equipment (again) and i will be making cannabis cookies with berries from a Berberis shrub in the garden.

their berries contain the alkaloid berberine which seem to suppress the growth of a wide variety of tumor cells and has lots of other medical uses

Berberine - Wikipedia, the free encyclopedia

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Old 11-01-2011, 10:48 AM
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Originally Posted by Gert Lush View Post
Hi Sensimilla13
Combined with what??

Won't that have the "interesting" side effect that you will be totally stoned out of your skull? Even as a seasoned smoker? Could you really inflict a high-dose ingestion on someone who was not familiar with cannabis? Is that what Simpson suggests?

Sounds very questionable. Wouldn't some local delivery system of the THC to the tumour be a better idea?
Remarkably, patients become acclimated quickly to the high THC dose in the Simpson oil. I am seeing that happen with our cancer patient friend as I type this, who 'flipped out' from an intense cannabis high on his first oil dose. but now is cruising more easily, saying the oil is giving him more like a buzz.

As for 'local delivery of the THC to the tumor' I don't think so, as THC works against cancer as an agonist at the cannabinoid receptors (turns them on effecting a biologic response(s)). The receptors are located throughout the brain and body. Also, all that I've read in papers about CBD and cancer is that in slowing cancer metastisis (what it is so far known for) it does not have an affinity for the cannabinoid receptors, but works in some different way. CBD then might possibly be delivered locally to affect tumors. In other words, CBD and THC act in two different ways against cancer. CBD, not acting through receptors, is believed to slow cancer cell metastitis (mobility) while THC, acting through receptors, restores the natural ability of a cancer cell to self-destruct.
Then the sign of the Son of Man will appear in the sky, and then all the people of the earth will mourn and they will see the Son of Man coming on the clouds of heaven with power and great glory.
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Old 11-01-2011, 11:04 PM
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See also:

J Clin Invest. 2009 May;119(5):1359-72.

Cannabinoid Action Induces Autophagy-Mediated Cell Death Through Stimulation of ER Stress in Human Glioma Cells.
Salazar M, Carracedo A, Salanueva IJ, Hernández-Tiedra S, Lorente M, Egia A, Vázquez P, Blázquez C, Torres S, García S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, González-Feria L, Iovanna JL, Guzmán M, Boya P, Velasco G.
Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.

Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3-dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
PMCID: PMC2673842, PMID: 19425170 [PubMed - indexed for MEDLINE]

DOWNLOAD FULL ARTICLE: Cannabinoid action induces autophagymediated
cell death through stimulation of ER stress in human glioma cells

Trends Pharmacol Sci. 2009 Aug;30(8):411-20. Epub 2009 Jul 14.

The Endocannabinoid System of the Skin in Health and Disease: Novel Perspectives and Therapeutic Opportunities.
Bíró T, Tóth BI, Haskó G, Paus R, Pacher P.
Department of Physiology, University of Debrecen, Research Center for Molecular Medicine, Debrecen 4032, Hungary.

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).
PMCID: PMC2757311, PMID: 19608284 [PubMed - indexed for MEDLINE]

DOWNLOAD FULL ARTICLE: The Endocannabinoid System of the Skin in Health & Disease

J Pharmacol Exp Ther. 2009 Nov 4. [Epub ahead of print]

Antitumorigenic Effects of Cannabinoids Beyond Apoptosis.
Freimuth N, Ramer R, Hinz B.
University of Rostock.

According to the World Health Organization the cases of death caused by cancer will have been doubled until the year 2030. By 2010 cancer is expected to be the cause of death number one. It is therefore necessary to explore novel approaches for the treatment of cancer. During past years the antitumorigenic effects of cannabinoids have emerged as an exciting field in cancer research. Apart from their proapoptotic and antiproliferative action, recent research has shown that cannabinoids may likewise affect tumor cell angiogenesis, migration, invasion, adhesion and metastasation. This review will summarize the data concerning the influence of cannabinoids on these locomotive processes beyond modulation of cancer cell apoptosis and proliferation. The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids.
PMID: 19889794 [PubMed - as supplied by publisher]
Download abstract
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Old 11-01-2011, 11:52 PM
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Each and every one of us can play the part of an activist to some degree. Being here at MNS is an act of activism. Simple as that. It all adds up until critical mass occurs, then change comes.
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Old 11-02-2011, 12:31 AM
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Share this info around to any and all doctors and academics. We will win this damn War on Drugs by educating the uneducated!
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Old 11-02-2011, 03:44 AM
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Originally Posted by Sensimilla13 View Post
Cancer cells do indeed express the Cannabinoid receptors...if they didn't then THC would not be able to activate apoptosis.

CBD does bind to the CB2 receptor but much less to the CB1 receptor.

Sensi - thought I knew what I was saying, I should have qualified a post on such a complex & changing subject by stating I know enough only to be dangerous, so watch where you step! This is not the domain of a geologist

I encountered this statement or one similar to it in several links, quickly found this one - Cannabidiol has no affinity for CB1 and CB2 receptors but acts as an indirect antagonist of cannabinoid agonists. Outdated, or misunderstood by me? As I recall it is also in better sources than WP. Well at least I teased out a burst of new postings on the subject - thanks for the expert info.
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Old 11-02-2011, 09:30 AM
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There is a really cool spirit of participation of members in this thread. Makes participating a pleasure. Thanks guys.
Each and every one of us can play the part of an activist to some degree. Being here at MNS is an act of activism. Simple as that. It all adds up until critical mass occurs, then change comes.
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Old 11-02-2011, 09:58 AM
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Keep up the good work, some very valuable information here. Great thread. Thankyou. Keep it coming.
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Old 11-02-2011, 03:34 PM
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Originally Posted by spice View Post
some minor points- the word 'hemp' oil as used by Mr. Simpson, is, I believe, a reference to the original, archaic usage of gthe word hemp, aka 'indian hemp', known as cannabis far and wide the world over until Harry Anslinger created the 'M' word in order to properly demonize cannabis/hemp in everyones mind so that industry could keep everyone from realizing that factories were un necessary when you have a plant that can do it all.

So much is understandable when seen in that light.

I do not begrudge Mr. S the usage of hyperbole to advance the cause, the basic science of apoptosis in cancer cells caused by CBD/THC is SOLID AS A ROCK....programmed cell death has been proven repeatedly to occur in vivo and in vitro when the concentration is high enough, hence the methodology.

Thinking that 'delivery to the site' would be advantageous is not always the case, sometimes invasive western methods aren't the answer.
The word 'hemp' appears to be defined in the major English language dictionaries like this:

hemp - cannabis

hemp - a family of plants, some of which are used to make rope and strong rough cloth and others of which are used to get the drug cannabis.

hemp - a plant with strong stems used for making rope. The drug marijuana is made from some types of hemp.

hemp - also called Indian hemp, marijuana. a tall, coarse plant, Cannabis sativa, that is native to Asia but naturalized or cultivated in many parts of the world and is the source of a valuable fiber as well as drugs such as marijuana and hashish. Compare cannabis.

These are mostly the number 1, or rarely number 2 def. given for the major dictionaries at One Look dictionary search.

Apparently it's the smart determined blue collar worker Mr. Simpson who is more the expert in the word's proper usage, in accord with major accepted dictionaries. Aside from the minor issue of using 'hemp' the right way, I sense a lot of intelligence and competence resides with this fellow.
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Old 11-03-2011, 04:03 PM
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i look forward for a cure but i tell u what after having cancer myself and loosing weight from chemo self medicationg has been great for me i feel great
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