i was asking about the 'human tumor lines' comment. do you know what exact cell line we are talking about, and whether they were in vitro or xenograft?
also I haven't recently looked into A.D.M.E. data for all the newly explored cannabinoids.
I recently synthesized some derivatives of some natural products as an extension of some drug development work i did as a pharmaceutical scientist, and Overton's rule came up (as a predictive tool for bioavailability).
I took the position that transporters can be very specific and effective, and that without good data conjecture is really not warranted - even in light of protein binding assays.
I should really read up on receptor cross talk and trafficking for cannabinoid family - do any specific references come to mind for you?
I'll will look into Sean's work though (i presume that he meant 'non-psychoactive cannabinoids compounds with structural "similarity" to delta9-THC)
many thanks,