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  #121  
Old 01-30-2012, 11:05 PM
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But still, if I had a serious case of cancer today, I'd think I'd want to cast my lot with THC as the primary medicine, an approach with better understanding backing it and more precedent. According to my understanding, THC has the most affinity for cannabinoid receptors. The phenomenon of apoptisis (defined as a type of cell death in which the cell uses specialized cellular machinery to kill itself) is mediated by the cannabinoid receptor system. That is what I believe I'd be most interested in as a cancer patient; cancer cell self DEATH (while leaving surrounding cells healthy). From available research literature it looks (at least in my layman's understanding) that THC is most strongly associated with apoptosis. The language I typically read with other cannabinoids, CBD or THCA and CBDA, is that either they have no affinity for receptors or a weaker affinity. For those cannabinoids, and acid forms of cannabinoids, anti-cancer effects are more described in terms of slowing or inhibiting tumor growth and metastisis, but not necessarily cell apoptosis modulated by the cannabinoid receptor system. My understanding could certainly be wrong being the amateur I am, and if there's anyone understanding it better (sensi 13 comes to mind) please offer your comments.
ED: In this post ref. above I was in serious error.
Since then I came across two research articles about CBD + THC synergy in fighting cancer. They affirmed the present use and future promise of cannabidiol or CBD, a cannabinoid that can reduce THC psychoactivity and create a positive synergistic effect with THC in fighting cancers.

Project CBD | CANNABIDIOL SCIENCE | FOR DOCTORS | FOR PATIENTS

CBD Enhances the Anticancer Effects of THC - Journal MCT - Marcu

(the 2nd article about brain cancer, but possibly applicable to other cancers)


The project CBD article in particular has a table on the fourth page that lists what THC & CBD, individually, are expected to do. This indicates that CBD, even though believed to bind only weakly to the cannabinoid receptors, nevertheless is associated with stimulating cancer cell destruction or apoptosis, a function mediated by the receptors. This was news to me, and now I better understand all the excitement about CBD, as it has many of the same effects as THC. Also combining THC with CBD in treatment creates synergistic effects, according to the papers, in which the efficacy of combined THC & CBD is greater than the sum.

Until I read these articles I was not at all clear about CBD vis-a-vis THC from a cancer treatment perspective. Just thought I'd spread some information for whoever may be looking, as I was and am.. as a result I will be ordering some appropriate high CBD seeds soon, as our cancer stricken friend says he's getting pretty tired of always being high (he has never developed much tolerance to the cannabis high). Sure wish I could just drive somewhere to get a cutting of a high CBD plant, such as in Michigan the only MMJ state in the midwest..
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Last edited by donb; 02-04-2012 at 11:07 PM.
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  #122  
Old 01-31-2012, 09:39 PM
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Default Dosing further questions

Hey guys, I have just finished reading this whole thread and I appreciate all the input. I read a bit about dosing and folks feeling the effects of the medicine and wanted a bit of feedback if possible.

My mother who has breast cancer and doing a natural route to cure it asked me about phoenix tears, so I got her set up with a little bit. After taking it for a week or so in very small doses she says she is brain dead and feels pretty loopy most of the time. She has never used any cannabis products before but I am legal here in Colorado so I am familiar with it. I saw others mentioning similar effects and I am wondering if this is normal due to some people just being more sensitive to the cannabis or is it just the norm over all with the tears? Will it go away with tolerance or will the increasing doses mean that these feelings are just part of the process?

She is going to talk with her muscle tester and herbologist about it, but was hoping to get actual anecdotal evidence as well.

Thanks!
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  #123  
Old 02-01-2012, 02:41 AM
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..I read a bit about dosing and folks feeling the effects of the medicine and wanted a bit of feedback if possible. My mother who has breast cancer and doing a natural route to cure it asked me about phoenix tears, so I got her set up with a little bit. After taking it for a week or so in very small doses she says she is brain dead and feels pretty loopy most of the time..
hi sittingone:
We have the same concern for our cancer patient friend (mentioned earlier in this thread) as you do with your Mom. Patients preferring not to be stoned most every hour of the day. We've given our friend plenty of oil made from a haze hybrid, pretty strong stuff. I intend soon to order Z Series (if available) or some other high CBD strain. The friend is tired of being high all the time and hasn't seemed to form much tolerance to THC so far. Reading Rick Simpson's Phoenix Tears Oil tek and other of his writings like Run from the Cure, he doesn't seem to believe it's much problem, but I guess it depends on the person. CBD has been indicated as synergistic combined with THC and enhancing anti-cancer action (see the two links in my previous post). It looks to this layman that it's best to combine THC & CBD, likely increase effectiveness, and subdue much of the psychoactivity of THC.

I haven't tried a high CBD:THC strain yet. The MNS Strains forum now has smoke reports in it under the Remedy Z series.
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  #124  
Old 02-04-2012, 07:55 PM
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Best to use high CBD strains because when both THC and CBD are present they work much more effectively than their separate effectiveness combined. Looks like the 1:1 ratio for most treatments like cancer, MS, RA etc is best. Searching for a THC/CBD tester atm,,,


Needed to make some oil so I followed Ricks guidelines. Didn't like the idea of using an industrial solvent so used 95% abv vodka instead. Really expensive though so might use ethanol next time. Started off with 3oz of bud/trim plus 5-6 grams of hash, ended up with 20ml of oil, and another 1/2 - 1 gram to collect so a decent return. Working wonders already!
As usual I photographed the process

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  #125  
Old 02-05-2012, 07:53 AM
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Unhappy

Phoenix Tears didn't cure this poor guy...
My Journey with cancer-Rick simpson oil#16 - YouTube
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  #126  
Old 02-05-2012, 08:45 AM
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That's really upsetting HHHG

We know cannabinoids kill cancer, that shouldn't even be up for dispute any longer. It kills cancer consistently in labs in tubes and mice. I think the problem's the variables with cannabinoid ratio's, think it's vital to use the correct cannabinoid ratios when treating aggressive cancers especially.

Due to the system being completely corrupt most patients have to hope they have the ideal cannbinoid ratios and high percentages in their medicine as there's no way of telling for most. On top of that most are fighting the chemo/radio therapy on top of the cancer! Then all the cancer research funds goes into further researching, but ignores the natural cure to instead research treatments that can FIRST AND FOREMOST be patented and be profitable.

A former pharmaceutical company worker/exec said in a documentary, ' In our industry the most important thing is not to kill anyone, the second most important thing is not to cure anyone'.

Am I right in saying that apricot kernels containing vitamin B-17 are great for fighting off cancer? And they're banned in america,,,

Last edited by Gnome; 02-05-2012 at 05:51 PM.
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  #127  
Old 02-05-2012, 08:26 PM
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Originally Posted by Gnome View Post
I think the problem's the variables with cannabinoid ratio's, think it's vital to use the correct cannabinoid ratios when treating aggressive cancers especially.
I believe THC had been assumed to be the most active and important constituent against cancer. Rick Simpson's PTO had to operate on that assumption for practical purposes, since nearly all available drug strains of Cannabis featured THC as by far the dominant cannabinoid over all others, including CBD. But in recent years some research concludes that THC & CBD when combined show an enhancement (synergy) in anti-cancer effect, such that the combination of the two fights cancer better than the sum of the two if they operated alone. That puzzled me for a long time because it's also been reported that THC binds to cannabinoid receptors strongly, and CBD binds weakly and in some cases not at all, and that apoptosis (selective, programmed cancer cell death) is mediated or regulated by the receptor system. It's probably a bit much for my layman understanding.

Beyond this specific CBD issue (which is driving completely new breeding now to medical marijuana), to my knowledge, there is no valid info about "correct" cannabinoid ratios for cancer fighting, and I doubt if anyone has sure knowledge that a 1:1 ratio of THC:CBD is the "best" ratio, though it could turn out to be the case. Rick Simpson's recommendation to use a "high quality Indica strain" appeared to relate only to it's more "restful" qualities compared with a typical Sativa, not to the THC:CBD ratios in which there aren't many instances of significant differences between Indicas and Sativas. With Indica, Simpson wrote, a cancer patient was more likely to get a good sleep and rest.

Now CBD will share the spotlight with THC as a cancer fighter, and when high CBD strains become much more available to the public at large, it should change the practice of Rick Simpson's Phoenix Tears or similar plans, or at least the preferred raw cannabis used to make the oil. That is why for the one guy we are giving this oil to, we are looking to switch to a high CBD cannabis to make it, because of the synergism now thought unavailable with either THC or CBD alone.
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Be like God, forgiving of all; "Truly I say to you, all sins will be forgiven..and whatever abusive and blasphemous things men say [and write]; but whoever speaks against the Holy Spirit never has forgiveness, but is in grasp of an eternal sin." from Mark 3 - asked the preacher what this meant & the man's answer amazed me..

Last edited by donb; 02-05-2012 at 08:37 PM. Reason: add links
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  #128  
Old 02-06-2012, 02:54 AM
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Lightbulb Countertop Distiller & frozen Alcohol Phoenix Tears tutorial

Essential Cannabis Hemp Oil Making Tutorial Using Safe Countertop Distiller & FROZEN Alcohol - YouTube

Cheaper alternatives...
http://www.rollitup.org/cooking-cann...ol-reflux.html
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Last edited by HHHG; 02-06-2012 at 03:18 AM.
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  #129  
Old 02-06-2012, 07:32 AM
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Originally Posted by donb View Post
I believe THC had been assumed to be the most active and important constituent against cancer. Rick Simpson's PTO had to operate on that assumption for practical purposes, since nearly all available drug strains of Cannabis featured THC as by far the dominant cannabinoid over all others, including CBD. But in recent years some research concludes that THC & CBD when combined show an enhancement (synergy) in anti-cancer effect, such that the combination of the two fights cancer better than the sum of the two if they operated alone. That puzzled me for a long time because it's also been reported that THC binds to cannabinoid receptors strongly, and CBD binds weakly and in some cases not at all, and that apoptosis (selective, programmed cancer cell death) is mediated or regulated by the receptor system. It's probably a bit much for my layman understanding.

Beyond this specific CBD issue (which is driving completely new breeding now to medical marijuana), to my knowledge, there is no valid info about "correct" cannabinoid ratios for cancer fighting, and I doubt if anyone has sure knowledge that a 1:1 ratio of THC:CBD is the "best" ratio, though it could turn out to be the case. Rick Simpson's recommendation to use a "high quality Indica strain" appeared to relate only to it's more "restful" qualities compared with a typical Sativa, not to the THC:CBD ratios in which there aren't many instances of significant differences between Indicas and Sativas. With Indica, Simpson wrote, a cancer patient was more likely to get a good sleep and rest.

Now CBD will share the spotlight with THC as a cancer fighter, and when high CBD strains become much more available to the public at large, it should change the practice of Rick Simpson's Phoenix Tears or similar plans, or at least the preferred raw cannabis used to make the oil. That is why for the one guy we are giving this oil to, we are looking to switch to a high CBD cannabis to make it, because of the synergism now thought unavailable with either THC or CBD alone.

Hi donb,
That's what I was trying to say regarding the enhanced effectiveness of both THC and CBD. Not quite as elegantly put lol. Studies I've read show that THC kills cancer cells alone but then in other studies they state that CBD enhance the effectiveness further. It looks like THC is still the magic compound. Maybe 1:1 ratios are not the most effective but not a bad place to start if the studies are true regarding CBD.

What concerns me is whether these studies are accurate. It would be in the pharmas interest to state that the most effective combination of compounds is a combination not achievable naturally in the plant. GW studies state that using a high CBD level for instance reduces the risk of mental health problems from the THC. Yet there's NO studies to back up mental health problems with THC, and Guzman's research contradicts the claim. 2 years of administering high doses of THC into mice and rats showed no alterations or adverse effects to brain function, or any other organ or bodily function.
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Last edited by Gnome; 02-06-2012 at 07:40 AM.
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  #130  
Old 02-06-2012, 09:02 AM
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We know cannabinoids kill cancer, that shouldn't even be up for dispute any longer. It kills cancer consistently in labs in tubes and mice. I think the problem's the variables with cannabinoid ratio's, think it's vital to use the correct cannabinoid ratios when treating aggressive cancers especially.
If it were so I wouldn't need to have tests for Colon Cancer!. I obviously hope that the lab tests done on rats and mice with regard to CB1 and CB2 receptors can transfer to humans in real life.. on brain tumors/prostate it seems to have an effect... this guy is my bet for seeing if it helps with bowels - Prof Chris Paraskeva, it also certainly seem to have an effect on angiogenesis.. but its too early to say cannabinoids kill all cancer! (just yet, but I'm hoping)

Last edited by hypocrite; 02-06-2012 at 09:22 AM.
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