Mr. Nice Forums  
Home History Strains Media Web Community Medical Marijuana Contact us Auctions

Go Back   MNS Forums > MNS Forums > 3. The daily news

LinkBack Thread Tools Display Modes
Old 02-10-2020, 10:32 PM
shantibaba's Avatar
Breeder and moderator
Join Date: Mar 2007
Posts: 1,505
Default Cannabis compound may be 30 times more powerful than THC, scientists find

Cannabis compound may be 30 times more powerful than THC, scientists find
Specific compounds found within the Italian medical cannabis variety known as FM2 using mass spectrometry and metabolomics, a common process designed for finding basic chemicals, may be 30 times as powerful as THC, as noted in a CNN report.
The authors assessed whether THCP has the ability to bind to human cannabinoid receptors found in the endocannabinoid system via lab experimentation. The role of the endocannabinoid system is for keeping bodies in homeostasis, or equilibrium, which also regulates sleep, appetite, inflammation to pain and more. When someone smokes cannabis, THC overwhelms the endocannabinoid system, which interferes with the person's ability to have their cannabinoid receptors communicate between neurons.

In this case, the THCP bound strongly to both receptors, at a strength 33 times more powerful than regular THC, and 63 times stronger than another compound called THCV. The recent finding may explain why some potent cannabis varieties have a stronger effect that goes beyond it being attributed to the amount of THC alone.
"This means that these compounds have higher affinity for the receptors in the human body. In cannabis varieties where THC is present in very low concentrations, then we can think that the presence of another, more active cannabinoid can explain those effects," said Dr. Cinzia Citti, lead author and post-doctoral fellow in life sciences at the University of Modena and Reggio Emilia in Italy.
In terms of how cannabinoids affect humans, the presence of 150 cannabis compounds is impacted by the alkyl side chain, which is typically five atoms long. In the case of THCP, a seven-atom chain, it has resulted in a higher potency than regular THC.
However, THCP has a seven-atom chain, meaning that in its natural form it has surpassed the potency of THC.
A cannabinoid with more than five atoms has never been previously reported as naturally occurring, as noted by the authors of the study. A cannabinoid with more than five atoms is also challenging to isolate.

"The challenge is that it can take a long time to isolate, especially with rare sources," said Dr. Jane Ishmael, associate professor in Oregon State University's College of Pharmacy. "I get the impression that these products were present in small amounts, so it's a surprise to find the natural products from a cannabis plant that we've known about for a long time."
As more people have become aware of the health benefits of CBD, but since THCP appears to be far more potent, the researchers believe that there can also be health benefits in this derivative form.
"There are other minor cannabinoids and traces in the plant that can be hard to study, but by isolation we can continue to assess the effects they might offer. Historically, many of our medicines have been derived by or inspired by natural products. By having new compounds that bind with very high affinity, that will give scientists a new probe into biological scientist," the authors said.

"Care about what other people think and you will always be their prisoner." -Lao Tzu

all the best,
Reply With Quote
Old 02-10-2020, 11:21 PM
Vlad the Inhaler's Avatar
Senior Member
Join Date: Jun 2016
Location: Perth
Posts: 410

This one goes a long way to explaining why some strains with moderate THC content can hit so far out of their class compared to supposed more potent strains.
Or why some landrace can be so scary to smoke.

It shows it binds at double for thcv as thc though.
Doesn't thcv bind to the receptor tighter than thc, and that's why it moderates thc effect.
Reply With Quote
Old 02-11-2020, 12:51 AM
bluntmassa's Avatar
Senior Member
Join Date: Jul 2012
Location: outlaw country,USA
Posts: 1,382

How nice it would be to have a testing lab. I'd grow a few of every strain available to get the highest levels of that THCP and then try like hell to get one 20% THCP. Though even 5% would be incredibly strong. Lol
Reply With Quote
Old 02-11-2020, 07:50 PM
Join Date: Dec 2019
Posts: 79

Thanks Shanti and here's the CNN link :
Reply With Quote
Old 02-15-2020, 07:11 PM
Senior Member
Join Date: Oct 2007
Posts: 320
Default for the science
Herbsman Hustlin
Reply With Quote

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

All times are GMT. The time now is 07:13 PM.

Powered by vBulletin® Version 3.8.11
Copyright ©2000 - 2020, vBulletin Solutions Inc.
SEO by vBSEO 3.6.0 PL2
All rights reserved, MR NICE SEEDBANK, NL